In the idyllic American town of Pleasant Hills, Pennsylvania, there lived a family with nine siblings, the youngest a girl named Barb. As the older children headed off to college and started their lives, only Barb was home to see their beautiful, still-young mother fall under a gothic spell, changing into someone she didn’t recognize: withdrawn, neglectful, uncaring. Thus begins The Vanishing Family, journalist Robert Kolker’s superb follow-up to Hidden Valley Road (“Deeply compassionate and chilling,” wrote The Washington Post). This family, we learn, has a genetic mutation that causes dementia, but with an especially cruel twist. As early as their forties, formerly loving parents and hard-driving executives will lose their jobs, have affairs, take up drinking—shed all inhibitions and sense of responsibility—and become people their families hardly know. Their former personalities seem to vanish—and there is a fifty-fifty chance that it will happen to their children, too.

The Vanishing Family unfolds like a heartbreaking thriller as the siblings begin to realize that what happened to their mother is happening to them: first one, then two, three, four, and more begin to change. Sue, in search of a calling, finds her place in caring for the others. Barb sets out to find a cure. Alongside their story, Kolker weaves in the dramatic scientific fight against dementia; after decades of blind alleys, this family’s rare form of FTD (frontotemporal dementia) might lead to a breakthrough in the prevention and treatment of all dementia—including the scourge of Alzheimer’s disease. Moving, intimate, unexpectedly hopeful and redemptive, The Vanishing Family is an enthralling narrative about one family’s fate, and a medical detective story that speaks to all of us who fear losing ourselves at the end.

Robert Kolker will be joined in conversation by bestselling author Laura Lippman. 

About the Author: 

Robert Kolker is a contributing writer at The New York Times Magazine and author of the #1 New York Times bestseller Hidden Valley Road, named an Oprah’s Book Club Pick, a New York Times Book Review Top 10 book of the year, a GQ Best Book of Literary Journalism of the 21st Century, and a Kirkus Reviews Best Nonfiction Book of the Century. His first book was Lost Girls, named a New York Times Notable Book and a Publishers Weekly Best Book of 2013.

About the Moderator: 

Laura Lippman is a New York Times best-selling novelist who has been called one of the "essential" crime writers of the last 100 years.  In 2025, she was named a Grandmaster by the Mystery Writers of America. She has published 26 novels, two short story collections, a book of essays, and one children's book. Her work has won or been shortlisted for every major prize given to crime novelists working in English. A limited series based on her 2019 novel Lady in the Lake, was released by AppleTV in 2024 starring Natalie Portman and Moses Ingram.  Laura lives in Baltimore and New Orleans. 

About the Program: 

• To attend in person please register here. 
• Doors will open to registered attendees at 6 pm. 
• A local bookseller will be on-site and have books available for purchase.
• Free parking vouchers are available to program attendees who park at the Franklin Street Garage (15 W. Franklin Street) after 4pm.  Ask Pratt event staff for your parking voucher prior to or after the program. 
• This free event will be presented in-person and virtually.   
• This is a seated event with spaces reserved for individuals with accessibility needs. ASL interpretation will also be available for attendees throughout the event. If you need additional accommodations to successfully participate, please let us know at events@prattlibrary.org or 443-768-0762.